Fitaro 1.7mg Injection

✔️ Composition

0.25 mg Injection:

• Each pre-filled syringe contains Semaglutide INN 0.25 mg in 0.5 ml solution for injection.

0.50 mg Injection:

• Each pre-filled syringe contains Fitaro INN 0.50 mg in 0.5 ml solution for injection.

1 mg Injection:

• Each pre-filled syringe contains Fitaro INN 1 mg in 0.5 ml solution for injection.

1.7 mg Injection:

• Each pre-filled syringe contains Fitaro INN 1.7 mg in 0.75 ml solution for injection.

2.4 mg Injection:

• Each pre-filled syringe contains Fitaro INN 2.4 mg in 0.75 ml solution for injection.

✔️ How does Fitaro 1.7mg/0.75ml Injection work?

Semaglutide is a medication that belongs to a class of drugs called glucagon-like peptide-1 receptor agonists (GLP-1 RAs). GLP-1 RAs mimic the action of glucagon-like peptide-1, a naturally occurring hormone that helps regulate blood sugar levels by stimulating insulin release and suppressing glucagon secretion. This results in lower blood sugar levels after meals and reduced appetite.

✔️ Side Effects

Possible side effects include hypersensitivity reactions, pancreatitis, and complications related to diabetic retinopathy.

✔️ Quick Suggestions:

• Eat at regular intervals.
• Avoid taking a long gap between meals or snacks.
• Monitor your blood sugar level regularly, especially during periods of significant fluctuations.
• Invest in at least 150 minutes of moderate-intensity physical activity per week.
• Include 15 minutes of exercise every week.
• Lose weight gradually to achieve a healthy body mass index (BMI) between 18.5 and 24.9.
• Replace refined carbohydrate-containing foods with whole-grain options.
• Increase the consumption of fruits, vegetables, and other fiber-enriched foods.
• Reduce the intake of saturated fat from foods like chips, crisps, pastries, biscuits, and samosas.
• Choose cooking oils containing omega-3 fatty acids for daily cooking.
• Avoid stress as it may elevate blood sugar levels.
• Adopt stress management techniques such as mindfulness, yoga, or meditation.
• Opt for low-fat dairy products, such as low-fat yogurt, fat-free milk, and cheese.
• Avoid drinking alcohol while on SEMAGLUTIDE to reduce the risk of hypoglycemia and lactic acidosis.
• Try to quit smoking.
• Reduce the intake of carbohydrate-rich foods like potatoes, rice, mangoes, bread, and sugar.
• Keep taking SEMAGLUTIDE even if your blood sugar levels are controlled until your doctor advises otherwise.
• Monitor your blood sugar frequently as recommended by your healthcare provider.
• Regularly monitor pancreatic enzymes, such as lipase and amylase.
• Take short, frequent meals.
• Avoid prolonged fasting when taking SEMAGLUTIDE.
• Be aware of hypoglycemia symptoms, including sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, and frequent urination.
• Carry 5-6 candies, three glucose biscuits, or three teaspoons of honey/sugar at all times, especially during long travels.
• Consume these immediately if experiencing hypoglycemia symptoms and contact your physician.

✔️ Indications:

Semaglutide is used to treat adults (aged 18 years and older) with type 2 diabetes when diet and exercise is not enough to control blood sugar levels.

✔️ Pharmacology

• GLP-1 analog with 94% sequence similarity to human GLP-1.
• Acts as a GLP-1 receptor agonist.
• Stimulates insulin secretion and lowers glucagon secretion in a glucose-dependent manner.
• Inhibits inappropriate glucagon secretion.
• Minor delay in gastric emptying.
• Reduces body weight and fat mass by reducing appetite.

✔️ Dosage:

Subcutaneous Injection:

• Starting dose: 0.25 mg once weekly for 4 weeks, then dose escalation over subsequent weeks.
• Maintenance dose: 2.4 mg once weekly.

✔️ Administration:

Injection Sites:

• Administer subcutaneously to the abdomen, thigh, or upper arm.

Frequency:

• Administer once weekly.

Day of Administration:

• Administer on the same day each week.
• The day of weekly administration can be changed if necessary, as long as the time between two doses is at least 2 days (>48 hours).

Timing:

• Administer at any time of the day.

Meal Consideration:

• Can be administered with or without meals.

Injection Site Rotation:

• Use a different injection site each week when injecting in the same body region.
• This rotation helps prevent irritation or changes at the injection site.

✔️ Interaction

Initiating Fitaro with Insulin Secretagogue or Insulin:

• Consider reducing the dose of concomitantly administered insulin secretagogue or insulin to reduce the risk of hypoglycemia.
• Caution with concomitant use of oral medications.

✔️ Contraindications

Do not use in patients with:

• Personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
• Hypersensitivity to Semaglutide.

✔️ Pregnancy & Lactation

Not recommended for pregnant women, nursing mothers

✔️ Precautions & Warnings

• Thyroid C-Cell Tumors:
  • Unknown if Fitaro causes thyroid C-cell tumors; monitor for signs.
• Pancreatitis:
  • Observe for signs; discontinue if suspected.
• Diabetic Retinopathy Complications:
  • Monitor for progression in patients with a history of diabetic retinopathy.
• Hypersensitivity:
  • Discontinue in case of hypersensitivity reactions.
• Use in Special Populations:
  • Pediatric use not established.
  • Geriatric use: No overall differences in safety or efficacy.
  • No dose adjustment for renal or hepatic impairment.

✔️ Storage Conditions

• Store in the refrigerator at 2°C to 8°C.
• After the first use, store for 56 days in the refrigerator.
• Do not freeze.
• Keep away from heat and light; keep the pen cap on when not in use.

✔️ Disposal

Unused cartridges may be used until the expiration date if kept in the refrigerator.